Real-time communication in ASP.NET Core can be achieved using technologies such as SignalR. SignalR provides a high-level API for building real-time web applications, allowing server-side code to push content to connected clients. With SignalR, you can implement features like real-time chat, live updates, or collaborative editing. To implement real-time communication in ASP.NET Core with SignalR, you need to create a SignalR hub that acts as a communication endpoint between the server and clients. The hub defines methods that can be called by clients or the server to exchange data. Clients can establish a connection to the hub using JavaScript libraries on the client side or by using the SignalR client libraries for other platforms. SignalR takes care of managing the connections, handling message routing, and ensuring real-time updates are delivered to connected clients efficiently.